Skip navigation
Please use this identifier to cite or link to this item:

Title: Assessment of the effects of the carbamazepine on the endogenous endocrine system of Daphnia magna
Authors: Oropesa, A.
Floro, António
Palma, Patrícia
Keywords: Crustacea
Daphnia magna
Issue Date: Sep-2016
Publisher: Springer
Citation: Oropesa, A.L., Floro, A.M., Palma, P. (2016). Assessment of the effects of the carbamazepine on the endogenous endocrine system of Daphnia magna. Environmental Science and Pollution Research, 23, 17311-17321.
Abstract: In the present study, the endocrine activity of the antiepileptic pharmaceutical carbamazepine (CBZ) in the crustacean Daphnia magna was assessed. To assess the hormonal activity of the drug, we exposed maternal daphnids and embryos to environmental relevant concentrations of CBZ (ranging from 10 to 200 μg/L) and to mixtures of CBZ with fenoxycarb (FEN; 1 μg/L). Chronic exposure to CBZ significantly decreased the reproductive output and the number of molts of D. magna at 200 μg/L. This compound induced the production of male offspring (12 ± 1.7 %), in a non-concentration-dependent manner, acting as a weak juvenile hormone analog. Results showed that this substance, at tested concentrations, did not antagonize the juvenoid action of FEN. Further, CBZ has shown to be toxic to daphnid embryos through maternal exposure interfering with their normal gastrulation and organogenesis stages but not producing direct embryo toxicity. These findings suggest that CBZ could act as an endocrine disruptor in D. magna as it decreases the reproductive output, interferes with sex determination, and causes development abnormality in offspring. Therefore, CBZ could directly affect the population sustainability.
Peer reviewed: yes
ISSN: 09441344
Appears in Collections:D-BIO - Artigos em revistas com peer review

Files in This Item:
There are no files associated with this item.

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Currículo DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.